5/28/2023 0 Comments Keecloud![]() Of those conditions, a common comorbidity in women with menopause is closely linked to the process of CKD development, which increases mortality ( Kattah et al., 2018 Vellanki and Hou, 2018). This process is presumed to have led to the emergence of a number of complications, such as hot flashes (or vasomotor symptoms), chronic kidney disease (CKD), cardiovascular disease, and neurodegenerative disease ( Schindler et al., 2009 Torres et al., 2017) ( Williamson et al., 2019). Women undergoing menopause are at an increased risk of ovarian dysfunction that will lead to systemic estrogen exhaustion and accelerate aging. These findings provide a comprehensive description of OVX-induced glutathione redox stress at multiple levels and support HPL therapy as an effective modulator in renal tissues to locally influence the glutathione metabolism pathway and subsequent redox homeostasis. Moreover, HPL restored alanyl-aminopeptidase (Anpep) expression and metabolite shifts, promoting antioxidative metabolite processing, and recovery. HPL exhibited the potential to maintain cellular redox homeostasis by inhibiting gamma-glutamyltransferase 1 (Ggt1) overexpression, along with promoting the efflux of accumulated toxic amino acids and their metabolites. Here, using combined proteomic and metabolomic approaches, we constructed a multi-scaled “HPL-disease-gene-metabolite” network to generate a therapeutic “big picture” that indicated an important link between glutathione redox stress and kidney impairment. (HPL) in menopause-induced kidney disease therapy is still ambiguous, we aim to explore the effects of HPL on systemic redox stress under ovariectomy (OVX)-induced kidney dysfunction conditions. Menopause and associated renal complications are linked to systemic redox stress, and the causal factors remain unclear.
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